Supplementation with FERTINATAL® DHEA can be initiated at any time in the menstrual cycle. The reason is that functioning ovaries constantly recruit fresh follicles out of the so-called resting follicle pool, to start a 3-4 months-long journey of maturation. The time periods when good testosterone levels are of crucial importance for maturing follicles are the so-called small-growing follicle stages, ranging from primary follicles to small antral follicles. If the microenvironment of ovaries does not offer follicles at those stages adequate testosterone levels, follicle maturation slows down and even still maturing follicles produce eggs of poorer quality.
Small growing follicles, however, still require at least 6-8 weeks of further maturation before they reach the last 2 weeks of the maturation journey, the so-called gonadotropin-dependent stage, where they become responsive to fertility drugs (those used in IVF cycles). This is the reason why pre-supplementation with FERTINATAL® must be initiated at least 6 weeks before the IVF cycle starts. If DHEA supplementation is given for shorter periods or only during ovarian stimulation with fertility drugs, the follicles receiving the DHEA's fertility benefits are still weeks to months away from the gonadotropin-dependent stage of follicle maturation, and the follicles available in the current treatment cycle will not have received significant benefits from DHEA supplementation.